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Ujited inclusion in Cohorts 2A and 2B patients should have histologically confirmed at primary diagnosis unresectable locally advanced or metastatic adrenocortical carcinoma. For inclusion in Cohorts 3A and 3B patients should have histologically confirmed at primary diagnosis unresectable malignant defined as metastatic disease, i. Patients who are human leukocyte antigen HLA -A2 positive.

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